溴化锌/溴化锂,以 25% 浓度的丁醚溶液形式提供
ZnBr2
溴化锌和溴化锂粉末容易飞扬,并有很强的吸湿性,使用“预制”丁醚溶液可避开这两大问题。
溴化锌/溴化锂丁醚溶液主要用于有机合成,例如:
- 通过金属交换反应将有机镁和有机锂化合物转化为相应的锌试剂,以用于 C-C 偶联反应(Negishi 偶联反应)
- 通过标准碱对羰基化合物进行去质子化后,使用溴化锌进行金属交换反应,生成烯醇锌
- 催化环加成反应,如富电子二烯与羰基化合物的 Diels-Alder 环加成反应
- 制备选择性还原剂,如让钠硼氢化物与溴化锌发生反应,生成硼氢化锌
参考文献:
McGarvey, G.J. in Encyclopedia of Reagents for Organic Synthesis, Paquette, L.A., Ed. John Wiley and Sons, New York (1995), Vol. 8, 5544
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