Zinc bromide/Lithium bromide, ca. 25 % in Dibutylether (extra dry)
ZnBr2
Zinc bromide/Lithium bromide (CAS 7699-45-8) is a stoichiometric mixture of ZnBr2 and LiBr. It is supplied as a typical 25% solution in dibutyl ether.
It is commonly used as a reagent for transmetallation to access Organozinc compounds for Negishi couplings. The use of a 'ready-made' dibutyl ether solution avoids the handling of the very hygroscopic and dusty ZnBr2 and LiBr powder.
Zinc bromide/Lithium bromide should be handled under dry, inert conditions. Consult the SDS and site-specific procedures for compatible materials, fire response, and storage.
Applications
The use of a 'ready-made' dibutyl ether solution avoids the handling of the very hygroscopic and dusty ZnBr2 and LiBr powder. The ZnBr2/LiBr dibutyl ether solution was developed mainly for the application in organic synthesis, e.g.: - transmetallation of organomagnesium and organolithium compounds to the corresponding zinc reagents for C-C coupling reactions (Negishi protocol) - formation of zinc enolates by deprotonation of carbonyl compounds using standard bases followed by transmetallation with ZnBr2 - catalysis of cycloaddition reactions e.g. Diels-Alder reactions of electron rich dienes with carbonyl compounds - preparation of selective reducing agents, e.g. Zn(BH4)2 by reaction ofNaBH4 with ZnBr2 Reference: McGarvey, G.J. in Encyclopedia of Reagents for Organic Synthesis, Paquette, L.A., Ed. John Wiley and Sons, New York (1995), Vol. 8, 5544
Specifications
- Zinc Bromide 23,0 - 27,0 %
- Lithium Bromide 8,0 - 12,0 %
- Water content max 0,02 %
- Bromide 25,0 - 29,0 %
Method of Analysis
Determination of assay ZnBr2 via complexometric potentiometric titration of Zn. LiBr calculated from Zn/Br content water via Karl-Fischer titration. Bromide via argentometric titrationHandling Instructions
Storage and handling under inert gas is recommended. Avoid contact with eyes, skin and clothes as well as inhalation. Never add oxidizing materials to the product. Vapors may form explosive mixtures with air. Vapors are heavier than air and may spread along floors. Flash-back possible over considerable distance. Use only explosion-proof equipment. Take measures against electrostatic discharges. Protect from frost, heat and sunlight. Pay attention to the Safety Data Sheet.
Storage Instructions
As ZnBr2/LiBr tends to crystallize from the solution material should be stored above 0 °C. When stored according to SDS the material is fairly stable. We still recommend to retest the material 9 months after date of analysis if included on CoA. If not included, use the date of manufacturing for the calculation.
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