Zinc Chloride, typ. 25 % solution in 2-Methyl-THF
ZnCl2
Zinc Chloride (CAS 7646-85-7) is a zinc salt with molecular formula ZnCl2. It is supplied as a typical 25% solution in 2-Methyl-THF.
It is commonly used as a reagent for transmetallation to access Organozinc compounds for Negishi couplings. The use of a 'ready-made' 2-Methyl-THF solution avoids the handling of the very hygroscopic and dusty ZnCl2 powder.
Zinc chloride should be handled under dry, inert conditions. Consult the SDS and site-specific procedures for compatible materials, fire response, and storage.
Applications
The use of a 'ready-made' 2-Methyl-THF solution avoids the handling of the very hygroscopic and dusty ZnCl2 powder. The ZnCl2 / 2-Methy-THF solution was developed mainly for the application in organic synthesis, e.g.: -transmetallation of organomagnesium and organolithium compounds to the corresponding zinc reagents for C-C coupling reactions (Negishi protocol). -formation of zinc enolates by deprotonation of carbonyl compounds using standard bases followed by transmetallation with ZnCl2. -catalysis of cycloaddition reactions e.g. Diels-Alder reactions of electron rich dienes with carbonyl compounds. -preparation of selective reducing agents, e.g. Zn(BH4)2 by reaction of NaBH4 with ZnCl2. Reference: McGarvey, G.J. in Encyclopedia of Reagents for Organic Synthesis, Paquette, L.A., Ed. John Wiley and Sons, New York (1995), Vol. 8, 5544.
Specifications
- Zinc Chloride 23,0 - 27,0 %
- Water content max 0.14 %
Method of Analysis
Determination of assay by argentometric titration of chloride, determination of water by Karl-Fischer titration.Handling Instructions
Storage and handling under inert gas is recommended. Avoid contact with eyes, skin and clothes as well as inhalation. Vapors may form explosive mixtures with air. Vapors are heavier than air and may spread along floors. Flash-back possible over considerable distance. Use only explosion-proof equipment. Take precautionary measures against electrostatic. Protect from frost, heat and sunlight. Pay attention to official safety regulations (see also 'Transport regulations' and 'Marking').
Storage Instructions
Storage As ZnCl2 tends to crystallize from the solution material should be stored above 0°C. When stored according to SDS the material is fairly stable. We still recommend to retest the material 6 months after date of analysis if included on CoA. If not included, use the date of manufacturing for the calculation. Pay attention to official safety regulations (see also: ”Transport regulations” and “Marking“).
Legal Disclaimer
The information presented herein is believed to be accurate and reliable but is presented without guarantee or responsibility on the part of Albemarle Corporation and its subsidiaries and affiliates. It is the responsibility of the user to comply with all applicable laws and regulations and to provide for a safe workplace. The user should consider any health or safety hazards or information contained herein only as a guide and should take those precautions which are necessary or prudent to instruct employees and to develop work practice procedures in order to promote a safe work environment. Further, nothing contained herein shall be taken as an inducement or recommendation to manufacture or use any of the herein materials or processes in violation of existing or future patent.
