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CHEMICAL SYNTHESIS

Your Trusted Partner for Chemical Synthesis Reagents

Empowering small molecule API manufacturing with precision, reliability and scale.

At Albemarle, we understand that the success of pharmaceutical, agricultural and fragrance innovation hinges on precision, reliability and scale. That’s why our Tools for Synthesis reagent portfolio is designed to empower manufacturers, originators and CDMOs with high-purity, performance-driven reagents—delivered at global production scale.

Our reagents for small molecule API manufacturing support customers across continents, while our close collaboration with CMC (Chemistry Manufacturing and Controls) teams aims to ensure that each reagent is tailored to their process needs, enabling smoother development and more efficient scale-up.

Precision Chemistry, Tailored to Your Needs

Optimal Reagent Selection
Our experts help customers select the optimal reagent for complex transformations by suggesting solvent systems, concentrations and solid particle characteristics to help meet their process needs.

Safety & Compliance at Every Scale
We assist with on-site technical support and guidance, audits and training to promote safe handling of our products. Additionally, our diverse fleet of returnable containers is designed to enhance safety and efficiency with a range of sizes, customizable fill levels and security-enhancing unloading features. Ask about our solvent-soluble bag (Secubags®) options to ease your solids’ handling.

Consistent High Quality
Our 50+ years of manufacturing expertise combined with sophisticated production capabilities and vertically integrated operations enable consistent, high-quality output—for even the most customized solutions. We leverage world-class process technology to deliver scalable, precision-grade reagent production. Contact us to learn more about our ISO and other manufacturing and quality certifications.

Supply Reliability, Wherever You Operate
With production facilities in Europe (Langelsheim, Germany), North America (New Johnsonville, USA) and Asia (Taichung, Taiwan) supported by a robust global distribution and warehouse network, we enable uninterrupted supply for wherever your operations are based.

Enabling a Broad Range of Organic Transformations

Albemarle’s Tools for Synthesis reagent portfolio enables a broad range of organic transformations including reductions, deprotonations, halogen-metal exchanges, C–C couplings, brominations and more. Our range of complex metal hydride reagents cover the full spectrum of reduction strengths, with adjustable nucleophilicity to improve yield and selectivity.

For halogen-metal exchange reactions, our Turbo Grignards enable efficient metalation of even challenging halides, delivering high-purity building blocks under milder conditions. To simplify scale-up and avoid handling of corrosive or hygroscopic solids, we offer salt solutions—such as zinc salts for accessing organozinc intermediates in Negishi couplings.

Download Our Product Portfolio

Specialty Reagents for Chemical Synthesis

Our diverse Tools for Synthesis portfolio includes:

Alkoxides
Metal amides
Bromine, alkyl bromides and other derivatives
Hydrides
Organomagnesium compounds (Grignards and Turbo Grignards)
Organolithium compounds
Specialty salts and anhydrous salt solutions
Cesium compounds

View our Product Line Portfolio to learn more. Looking for a reagent you don't see in our Product Portfolio? Contact us to learn about our custom reagent manufacturing.

Pharmaceutical-Grade Lithium Carbonate

Albemarle is a provider of select Active Pharmaceutical Ingredients (API), aligned to various global standards, for the manufacture of drugs and medications to help provide their intended therapeutic effect.

More Information

Looking for custom reagents, SDS, TDS, certifications or quality statements? Contact us for more information.

Driving Precision in Drug Manufacturing

Our reagents are used in the most critical steps of many commercial drugs manufacturing where optimization of yield, selectivity and reliability are paramount.

Whether you are in early-stage route selection or preparing for scaling and commercial launches, we recommend engaging with us early on in drug manufacturing development efforts so that we can help you: