Phenyllithium, typ. 20 % solution in Dibutyl Ether (1.9 M)
C6H5Li
Phenyllithium (CAS 591-51-5) is an organolithium reagent with molecular formula C6H5Li. It is supplied as a typical 20% solution in Dibutyl Ether.
Phenyllithium is commonly used as a nucleophile in organic synthesis. Typical applications include arylation and also halogen-lithium exchange.
Phenyllithium reacts readily with moisture and oxygen and should be handled under dry, inert conditions. Consult the SDS and site-specific procedures for compatible materials, fire response, and storage.
Applications
Reagent for the introduction of a phenyl group and mild metalating agent.
Specifications
- Total base: 18,0 - 21,0 %
- Active base: 17,6 - 20,4 %
- Chlorobenzene: max. 0,1%
- Biphenyl: max. 2,4 %
- Sum Hexane: max. 1,5 %
- Benzene: max. 1,0 %
- MTBE: max. 0,1 %
Method of Analysis
Determination of total base by potentiometric titration. Determinatioon of active base by thermometric titration. Chlorbenzene, Biphenyl, sum Hexanes, Benzene and MTBE are detected by GC. Detailed description available on request.Handling Instructions
Phenyllithium should only be handled under inert gas atmosphere. Avoid contact with eyes, skin and clothes as well as inhalation. Vapors may form explosive mixtures with air. Vapors are heavier than air and may spread along floors. Flash- back possible over considerable distance. Use only explosion-proof equipment. Take measures against electrostatic discharges. Protect from frost, heat and sunlight. Never add water, acids or oxidizing materials to the product. In case of fire use dry extinguishers on basis of sodium chloride or limestone powder. Never use water or CO2-extinguishers. Pay attention to the safety data sheet.
Storage Instructions
When stored according to SDS the material has limited stability due to decomposition over time. We therefore recommend to retest the material 6 months after date of analysis if included on CoA. If not included, use the date of manufacturing for the calculation. The material should be stored at temperatures between -5 and +9°C. Decomposition does not cause appreciable pressure build up. Keep container tightly closed.
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