Methyllithium, typ. 6 % solution in Diethyl Ether with Lithium Bromide (typ. 2.2 M)
CH₃Li
Methyllithium (CAS 917-54-4) is an organolithium reagent (strong base/nucleophile) with molecular formula CH3Li. It is supplied as a typical 6% solution in Diethyl Ether with Lithium Bromide.
It is commonly used as a strong base for selective deprotonation and related transformations. Methylating agent. Lithiation of organic compounds. The solution contains lithium bromide as a complexing agent. This increases selectivity and reduces reactivity of Methyllithium.
Many reagents in this class react readily with moisture and oxygen. Handle under dry, inert conditions using air‐ and water‐free techniques, and add slowly/with cooling when quenching or charging to control heat release. Consult the SDS and site-specific procedures for compatible materials, fire response, and storage.
Applications
Methylating agent. Lithiation of organic compounds. The solution contains lithium bromide as a complexing agent. This increases selectivity and reduces reactivity of Methyllithium.
Specifications
- Total base 6,0 - 7,0 %
- Active base 6,0 - 6,3 %
- LiBr 9,0 - 11,0 %
Method of Analysis
Determination of assay as total base by potentiometric titration after hydrolysis. Determination of assay as active base by thermometric titration. LiBr analyzed by argentometric / potentiometric titration.Handling and Storage
Handling Instructions
Methyllithium should only be handled under inert gas atmosphere. Catches fire spontaneously if exposed to air. Avoid contact with eyes, skin and clothes as well as inhalation. Vapors may form explosive mixtures with air. Vapors are heavier than air and may spread along floors. Flash-back possible over considerable distance. Use only explosion-proof equipment. Take measures against electrostatic discharges. Protect from frost, heat and sunlight. Never add water, acids or oxidizing materials to the product. In case of fire use dry extinguishers on basis of sodium chloride or limestone powder. Never use water or CO2-extinguishers. Pay attention to the safety data sheet.
Storage Instructions
Recommended storage temperature: 5-15 °C. Keep container tightly closed. When stored according to SDS the material has limited stability due to decomposition over time. We therefore recommend to retest the material 6 months after date of analysis if included on CoA. If not included, use the date of manufacturing for the calculation.