Zinc pivalate x Lithium chloride, typ 22% in 2-Methyl-THF
C10H18ClLiO4Zn
Zinc pivalate × lithium chloride (CAS 7646-85-7) is a mixed lithium/zinc salt with molecular formula C10H18ClLiO4Zn. It is supplied as a typical 22% solution in 2-Methyl-THF.
It is commonly used as a reagent for transmetallation to access Organozinc compounds for Negishi couplings. The use of a 'ready-made' 2-Methyl-THF solution avoids the handling of the very hygroscopic and dusty Zinc pivalate and Lithium Chloride powder. Zinc pivalate facilitates Mg insertion into carbon-halogen bonds compared to ZnCl2. The resulting Organozinc pivalate reagents show good stability and solubility as well as improved reactivity in Negishi couplings.
Zinc pivalate × lithium chloride should be handled under dry, inert conditions. Consult the SDS and site-specific procedures for compatible materials, fire response, and storage.
Applications
Zinc pivalate × lithium chloride is commonly used as a reagent for transmetallation to access Organozinc compounds for Negishi couplings. The use of a 'ready-made' THF solution avoids the handling of the very hygroscopic and dusty Zinc pivalate and Lithium Chloride powder. Zinc pivalate facilitates Mg insertion into carbon-halogen bonds compared to ZnCl2. The resulting Organozinc pivalate reagents show good stability and solubility as well as improved reactivity in Negishi couplings.
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