tert-Butyllithium, typ. 18 % solution in Heptane (typ. 2.0 M)
C4H9Li
tert-Butyllithium (CAS 594-19-4) is an organolithium reagent with molecular formula C4H9Li. It is supplied as a typical 18% solution in Heptane.
tert-Butyllithium is commonly used as a strong base and nucleophile in organic synthesis. Typical applications include alkylation, deprotonation and also halogen-lithium exchange.
tert-Butyllithium reacts readily with moisture and oxygen and should be handled under dry, inert conditions. Consult the SDS and site-specific procedures for compatible materials, fire response, and storage.
Applications
Alkylating and metalating agent. Reagent for the introduction of the tert-butyl group.
Specifications
- Magnesium tert-Butoxide: min. 93 %
Method of Analysis
Determination of assay as active base. Detailed description available on request.
Handling Instructions
tert.-Butyllithium should only be handled under inert gas atmosphere. Catches fire spontaneously if exposed to air. Avoid contact with eyes, skin and clothes as well as inhalation. Vapors may form explosive mixtures with air. Vapors are heavier than air and may spread along floors. Flash-back possible over considerable distance. Use only explosion-proof equipment. Take measures against electrostatic discharges. Protect from frost, heat and sunlight. Never add water, acids or oxidizing materials to the product. In case of fire use dry extinguishers on basis of sodium chloride or limestone powder. Never use water or CO2-extinguishers. Pay attention to the safety data sheet.
Storage Instructions
When stored according to SDS the material has limited stability due to decomposition over time. We therefore recommend to retest the material 6 months after date of analysis if included on CoA. If not included, use the date of manufacturing for the calculation. The danger of ignition is enhanced if the solution comes in contact with surface rich materials (paper, textiles) or if it is sprayed. To keep the quality a storage of 0-10 °C is recommended. The solution should be stored in tightly closed containers in a well ventilated cool place.
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