Methylmagnesium Chloride, typ. 22 % solution in THF (typ. 3 M)
CH3ClMg
Methylmagnesium Chloride (CAS 676-58-4) is an organomagnesium compound (Grignard reagent) with molecular formula CH3ClMg. It is supplied as a typical 22% solution in THF.
In organic synthesis it is used in Grignard-type reactions as a reactive carbon nucleophile or in deprotonation reactions as a base.
Methylmagnesium Chloride reacts readily with moisture and oxygen and should be handled under dry, inert conditions. Consult the SDS and site-specific procedures for compatible materials, fire response, and storage.
Applications
Grignard-reactions: reagent for the introduction of the methyl group.
Specifications
- Methylmagnesium Chloride: 21.0 - 23.0 %
Method of Analysis
Determination of assay as total base by acidimetric titration after hydrolysis; detailed description available on request.Handling Instructions
Organomagnesium compounds should only be handled under inert gas (nitrogen or argon). Never add water, acids or oxidizing materials to the product. Vapors may form explosive mixtures with air. Vapors are heavier than air and may spread along floors. Flash back possible over considerable distance. Use only explosion-proof equipment. Protect from frost, heat and sunlight. In case of fire use dry extinguishers on basis of sodium chloride or limestone powder. Never use water or CO2-extinguishers. Pay attention to official safety regulations (see also: ”Transport regulations” and “GHS Hazard Pictograms“).
Storage Instructions
When stored according to SDS the material is fairly stable. We still recommend to retest the material 6 months after date of analysis if included on CoA. If not included, use the date of manufacturing for the calculation. As material tends to crystallize at lower temperatures, it should be stored above 10 °C. Keep container dry and tightly closed.
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