Methyllithium, typ. 5 % solution in Diethyl Ether (typ. 1.6 M)
CH3Li
Methyllithium (CAS 917-54-4) is an organolithium reagent with molecular formula CH3Li. It is supplied as a typical 5% solution in Diethyl Ether.
Methyllithium is commonly used as a strong base or nucleophile in organic synthesis. Typical applications include alkylation, deprotonation and halogen-lithium exchange.
Methyllithium reacts readily with moisture and oxygen and should be handled under dry, inert conditions. Consult the SDS and site-specific procedures for compatible materials, fire response, and storage.
Applications
Alkylating and metalating agent.
Specifications
- Methyllithium: 4.5 – 5.5 %
Method of Analysis
Determination of assay as total base by potentiometric titration after hydrolysis; detailed description available on request.Handling Instructions
Methyllithium should only be handled under inert gas atmosphere. Catches fire spontaneously if exposed to air. Avoid contact with eyes, skin and clothes as well as inhalation. Vapors may form explosive mixtures with air. Vapors are heavier than air and may spread along floors. Flash-back possible over considerable distance. Use only explosion-proof equipment. Take measures against electrostatic discharges. Protect from frost, heat and sunlight. Never add water, acids or oxidizing materials to the product. In case of fire use dry extinguishers on basis of sodium chloride or limestone powder. Never use water or CO2-extinguishers. Pay attention to the safety data sheet.
Storage Instructions
When stored according to SDS the material has limited stability due to decomposition over time. We therefore recommend to retest the material 6 month after date of analysis if included on CoA. If not included, use the date of manufacturing for the calculation. Recommended storage temperature: 5-10 °C. Keep container tightly closed.
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