Product Safety Code
Albemarle has an extensive program to determine, mitigate, and manage the risk associated with our products.
Albemarle will consider product safety and environmental impact issues or our products through the entire cycle, including inception, design, development, manufacture, storage, transportation, distribution, marketing, use and disposal.
Product Safety Management Priority Scheme Hazard Assessment Matrix
Endpoint assessed | Very Low Hazard Potential: Score 1 | Low Hazard Potential: Score 2 | Medium Hazard Potential: Score 3 | High hazard potential: Score 4 |
Acute oral toxicity | GHS cat 5 LD50 > 2000 mg/kg bw | GHS cat 4 LD50 > 300 ≤ 2000 mg/kg bw | GHS cat 2 and 3 LD50 > 5 ≤ 300 mg/kg bw | GHS cat 1 LD50 ≤ 5 mg/kg bw |
Acute dermal toxicity | GHS cat 5 LD50 > 2000 mg/kg bw | GHS cat 4 LD50 > 1000 ≤ 2000 mg/kg bw | GHS cat 2 and 3 LD50 > 50 ≤ 1000 mg/kg bw | GHS cat 1 LD50 ≤ 50 mg/kg bw |
Acute inhalation toxicity | GHS cat 5 LC50 > 5000 ppm (gas), or > 20 mg/L Vapor, or > 5 mg/L dust aerosol | GHS cat 4 LC50 > 2500 ≤ 5000 ppm (gas), or > 10 ≤ 20 mg/L Vapor, or > 1 ≤ 5 mg/L dust aerosol | GHS cat 2 and 3 LC50 > 100 ≤ 2500 ppm (gas), or > 0.5 ≤ 10 mg/L Vapor, or > 0.05 ≤ 1 mg/L dust aerosol | GHS cat 1 LC50 ≤ 100 ppm (gas), or 0.5 mg/L Vapor, or 0.05 mg/L dust aerosol |
Specific target organ effects after single exposure | Not classified no specific target organ effects observed | GHS SE Cat. 3 reversible acute target organ effects in humans or animals or respiratory tract irritation. | GHS STOT SE Cat. 2: Severe target organ toxicity. Human evidence or: oral rat > 300 mg/kg ≤ 2000 mg/kg; dermal rat or rabbit: > 1000 ≤ 2000 mg/kg; 4 h inh. Rat > 2500 ≤ 20,000 ppm (gas), or > 10 ; mg/L ≤ 20 mg/L vapor, or > 1 ≤ 5 mg/L dust, aerosol | GHS STOT SE category 1: human evidence or severe effects observed at ≤300 mg/kg oral rat, ≤ 1000 mg/kg dermal rat or rabbit, ≤ 2500 ppm rat 4 h gas or ≤ 10 mg/L vapour rat 4 h, or ≤ 1 mg/L 4 h rat dust, aerosol |
Irritation skin | Not irritating | GHS cat 3 irritant, animal 4 h reversible ≥ 1.5 < 2.3 for erythema/eschar in 2 of 3 animals and GHS cat 2 irritant, animal: 4h exposure rev. damage mean ≥ 2.3 <4 erythema, eschar or edema, or inflamation persisting in 2 of 3 animals, or surrogate valid data | UN GHS cat 1 A/B/C skin corrosive: animal irreversible damage to skin after up to 4 h of exposure or surrogate data | |
Irritation eye | Not irritating | UN GHS 3 mild irritant: fully reversible lesions in animals within 7 days or human experience and UN GHS cat 2A animal corneal opacity ≥ 1 < 3, or Iritis ≥ 1 < 3 or conjuctival redness or chemosis ≥ 2 in 2 of 3 animals, or surrogate data | UN GHS cat 1 eye corrosive: animal irreversible damage to eye or cornea opacity ≥ 3 and or iritis > 1.5 in 2 of 3 animals, or surrogate data | |
Sensitization respiratory and skin | Not sensitizing | CLP cat 1B weak animal skin sensitizer, or good epidemiological evidence that no human sensitizer | UN GHS cat 1, CLP cat 1A or 1 strong Skin sensitizer or potency cannot be assessed: positive animal tests or human experience | UN cat 1 Respiratory sensitizer mostly based on human evidence |
Mutagenicity | Not mutagenic in at least 3 in vitro assays, or if positive, proof that not mutagenic in vivo for the relevant genetic endpoint | positive in one in vitro assay and no in vivo data available. | UN GHS Cat. 2 positive in vivo genotoxicity assays in somatic cells | UN GHS cat 1 A/B Known germ cell mutagen |
Carcinogenicity | Not classified based on sufficient data | No data on carcinogenicity and absence of indications in repeated dose and mutagenicity tests. | UN GHS cat. 2 suspected carcinogen based on limited data or threshold mode of action demosntrated | UN GHS cat 1 A/B known or presumed human carcinogen, animal carcinogen |
Repeated dose toxicity | No effects at the limit dose for repeated dose studies: 1000 mg/kg/d oral and.or dermal, rat, inhal, 6 h/d, 5d/week: 20000 ppm (gas), 20 mg/L vapor; 5 mg/L dust or aerosol or at the saturation or maximum attainable conc. | Effects not classifyable under UN GHS, but observed below a limit dose of 1000 mg/kg bw/d for repeated dose exposures via the oral and dermal route, for inhalation 6 h/d 5d/week rat: < 20,000 ppm (gas), < 20 mg/L for vapours, < 5 mg/L dust, aerosol; or below the saturation conc or max attainable conc. for inhalation studies. | UN GHS, CLP STOT cat 2. Human experience or animal studies based on 90d exposure severe target organ effects observed at > 10, ≤ 100 mg/kg bw/d oral rat; > 20, ≤ 200 mg/kg/d dermal rat or rabbit; inhalation rat 6 h/d 5d/week: > 50, ≤ 250 ppm (gas) or > 0.2, ≤ 1 mg/L (vapour) or > 0.02, ≤ 0.2 mg/L dust or aerosol. (for 28 d exposure :3) | GHS cat 1 CLP STOT cat 1. Specific target organ toxicity. Human evidence or animal studies based on 90d exposure severe target organ effects observed at ≤ 10 mg/kg bw/d oral rat; 20 mg/kg/d dermal rat or rabbit; inhalation rat 6 h/d 5d/week: ≤ 50 ppm (gas) or ≤ 0.2 mg/L (vapour) or ≤ 0.02 mg/L dust or aerosol. (for 28 d exposure :3) |
Toxicity to reproduction fertility | No effects in adequate studies. | Not classified, but some specific effects at NOAEL > 300 ≤ 1000 mg/kg bw | UN GHS cat. 2 . NOAEL > 1 ≤ 100 mg/kg bw/d (ICCA) | UN GHS category 1 A/B for fertility. Human evidence or animal studies. NOAEL ≤ 1 mg/kg bw/d (ICCA) |
Toxicity to reproduction developmental and lactation | No effects in adequate studies. | Not classified, but some specific effects at NOAEL > 300 ≤ 1000 mg/kg bw | UN GHS cat. 2 . NOAEL > 1 ≤ 100 mg/kg bw/d (ICCA) | UN GHS category 1 A/B for fertility. Human evidence or animal studies. NOAEL ≤ 1 mg/kg bw/d (ICCA) |
Acute ecotoxiicty (aquatic) | No classification. No acute toxicity at or above 100 mg/L or at solubility limit | UN GHS Cat 3. EC50, daphnia 48 h > 10, ≤ 100 mg/L or EC50, 72 h growth rate algae > 10, ≤ 100, or LC50 96 h fish > 10, ≤ 100 | UN GHS Cat 2. EC50, daphnia 48 h > 1, ≤ 10 mg/L or EC50, 72 h growth rate algae > 1, ≤ 10, or LC50 96 h fish > 1, ≤ 10 | UN GHS Cat 1. EC50, daphnia 48 h ≤ 1 mg/L or EC50, 72 h growth rate algae ≤ 1 mg/L or LC50 96 h fish ≤ 1 mg/l |
Chronic toxicity aquatic | Not classified or Cat 4: if poorly soluble and no acute toxicity up to solubility limit and not rapidly biodegradable or BCF ≥ 500, or log Kow ≥ 4 unless chronic NOECs are > 1 mg/L | UN GHS Cat 3. EC50, daphnia 48 h > 10, ≤ 100 mg/L or EC50, 72 h growth rate algae > 10, ≤ 100, or LC50 96 h fish > 10, ≤ 100 and not rapidly biodegradable or BCF ≥ 500, or log Kow ≥ 4 unless chronic NOECs are > 1 mg/L | UN GHS Cat 2. EC50, daphnia 48 h > 1, ≤ 10 mg/L or EC50, 72 h growth rate algae > 1, ≤ 10, or LC50 96 h fish > 1, ≤ 10 and not rapidly biodegradable or BCF ≥ 500, or log Kow ≥ 4 unless chronic NOECs are > 1 mg/L | UN GHS Cat 1. EC50, daphnia 48 h ≤ 1 mg/L or EC50, 72 h growth rate algae ≤ 1 mg/L or LC50 96 h fish ≤ 1 mg/l and not rapidly biodegradable or BCF ≥ 500, or log Kow ≥ 4 |
Flammability (flah point FP) | UN GHS level 4: FP > 60 deg. C, ≤ 93 deg. C or higher | UN GHS level 3: FP > 23 deg. C but ≤ 60 deg. C | UN GHS level 2FP ≤ 23 deg C and initial boiling point > 35 deg. C | UN GHS level 1FP ≤ 23 deg C and initial boiling point ≤ 35 deg. C |
Reactivity | No reactivity | unstable when heated or under pressure, not reactive with water | Unstable, detonable, reactive with water | Readily detonates or explodes and decomposes under normal temperature and pressure. |